As the world seeks to build back better from the COVID-19 pandemic, the 2023-2028 strategy of the Global Fund to fight AIDS, TB and Malaria could be instrumental in supporting governments to deliver resilient and sustainable health systems and to improve global health security. The bi-directional relationship between noncommunicable diseases (NCDs: inter alia cancer, respiratory disease, cardiovascular disease and diabetes), HIV and TB reduces quality of life, undermines treatment outcomes  and leads to premature mortality.  The Global Fund has a valuable opportunity to accelerate achievement of targets, while simultaneously addressing evolving community needs through cost-effective, evidence-based health interventions for NCDs.